CLEM on graphene liquid cells

We published a new paper describing CLEM imaging used in finding graphene liquid cells for TEM 

Graphene liquid cells for transmission electron microscopy enable high‐resolution, real‐time imaging of dynamic processes in water. However, large‐scale implementation is prevented by difficulties in reproducing graphene liquid cells. Together with the grop of Gregory Schneider from Leiden University, we publihed new findings in Advanced Functional Materials, describing a high‐yield method to fabricate large areas of graphene liquid cells on an electron microscopy support grid.

Graphene liquid cells are located on the grid using correlated light‐electron microscopy (CLEM), which reduces beam damage by limiting electron exposure time. CLEM allows the acquisition of reliable statistics and the investigation of the most common shapes of GLCs. The methods presented in this work, particularly the reproducibility and simplicity of fabrication, will enable future application of GLCs for high‐resolution dynamic imaging of biomolecular systems.


Graphene Liquid Cells Assembled through Loop‐Assisted Transfer Method and Located with Correlated Light‐Electron Microscopy (2019) Pauline M. G. van Deursen, Roman I. Koning, Viorica Tudor, Mohammad‐Amin Moradi, Joseph P. Patterson, Alexander Kros, Nico A. J. M. Sommerdijk, Abraham J. Koster, Grégory F. Schneider. Advanced Functional Materials, first published: 03 February 2020.

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