The significance of circadian biology has recently been emphasized by the Nobel Prize in Physiology or Medicine for the discoveries of molecular mechanisms controlling the circadian rhythm. The Nobel Prize awardees now published a perspective with various experts in this field (including Joke Meijer, CCB) on implementing circadian factors in pre-clinical studies, and even more importantly when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This suggests that the biology of the target cell will determine how an organ will respond to a drug at a specific time of the day, thus modulating pharmacodynamics. Thus, it is now time that circadian factors become an integral part of translational research.
Medicine in the Fourth Dimension. Christopher R. Cederroth, Urs Albrecht, Joseph Bass, Steven A. Brown, Jonas Dyhrfjeld-Johnsen, Frederic Gachon, Carla B. Green, Michael H. Hastings, Charlotte Helfrich-Förster, John B. Hogenesch, Francis Lévi, Andrew Loudon, Gabriella B. Lundkvist, Johanna H. Meijer, Michael Rosbash, Joseph S. Takahashi, Michael Young, Barbara Canlon. Cell Metabolism, Volume 30, Issue 2, 6 August 2019, Pages 238-250.