Modelling human RAG2-SCID using iPSC

Harald Mikkers and colleagues published in this week’s edition of Stem Cell Reports that the defect in T cell development in patients suffering from severe combined immunodeficiency due to mutations in the RAG2 gene is different from the defect observed in RAG2 mutant mice.

They used patient-derived induced pluripotent stem cells (iPSC) to demonstrate that the development of T lymphocytes is compromised during several early stages of T cell differentiation. As a consequence these SCID cells develop into natural killer (NK) cells. The authors believe that their system can aid in the categorization of different SCID mutations.

Collaborate with us

Please contact us if you are interested in a scientific collaboration, electron microscopy services, or would like to be trained. 

Read more