RNA replication in the absence of Replication Organelles

The dogma that membrane rearrangements are indispensable for genome replication and innate immune evasion is challenged.

Enterovirus replication sets up camp in the Golgi in the absence of replication organelles, challenging the paradigm that these virus-induced membrane rearrangements are indispensable for genome replication and innate immune evasion. The membrane-supported replication strategy of enterovirus extends to other important human pathogens, like SARS and MERS coronaviruses, hepatitis C viruses and Zika virus.

 

This work was carried out in collaboration between the Leiden Universtiy Medical Center, Utrecht University and the Radboud Institute for Molecular Life Sciences (Nijmegen).

Melia, C.E., van der Schaar, H.M., Lyoo, H., Limpens, R., Feng, Q., Wahedi, M., Overheul, G.J., van Rij, R.P., Snijder, E.J., Koster, A.J., Barcena, M. and van Kuppeveld, F.J.M., "Escaping Host Factor Pi4kb Inhibition: Enterovirus Genomic Rna Replication in the Absence of Replication Organelles" (2017) Cell Rep, 21, 3, 587-599.

DOI: 10.1016/j.celrep.2017.09.068.

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