In our new study, now publicly available in Science, we identify a molecular pore that spans the double membrane of the coronavirus replication organelle and likely serves as an RNA export channel. This protein complex would provide the long sought connection between the interior of the replication organelle and the cytosol, and offers a new target for antiviral drug development.
A new study led by the Medical Microbiology department characterizes different aspects of the replication of the new coronavirus in cell culture. Electron microscopy reveals progeny virions being assembled and released and the dramatic changes that occur in infected cells.
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