Georg Wolff

Georg Wolff

Georg studied Molecular Biotechnology for a BSc and subsequently a MSc at the University of Heidelberg, Germany. During his masters, he had the opportunity do an internship at the cryo-EM lab of Kay Grünewald in Oxord, UK and worked on the correlation of super-resolution and electron microscopy in cryo-conditions with Rainer Kaufmann. Since then he was hooked to (cryo)-EM and after his master thesis on a novel mass-spectrometry workflow in the lipidomics lab of Britta Brügger (Centre for Biochemistry of the University of Heidelberg, Germany) he headed for a Ph.D. in the field of cryo-EM.

In autumn 2017 Georg joined the Koster Lab as a Ph.D. student within the Virus Replication group led by Montserrat Bárcena, which closely collaborates with the Molecular Virology group of Prof. Eric Snijder, LUMC (Department of Medical Microbiology).  His research focus is on the viral replication organelles that Nidoviruses like coronaviruses (e.g. SARS-CoV, MERS-CoV) or arteriviruses (e.g. EAV) induce in their host cells. By facilitating state-of-the-art cryo-EM and correlative microscopy techniques he seeks to shed light on the molecular organization of these structures in their native environment. By the preparation of cryo-samples with Focused-Ion-Beam (FIB) Milling he will be able to visualize these structures in situ with macromolecular resolution. This should give us a better understanding of the so far unclear functionality and molecular organization of the virus-induced replication organelles.

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