Sebastiaan Hamers joined the Sharp lab in September 2020 as a PhD student. Sebastiaan’s project involves modulating the complement cascade. He will develop a rational, structure-based approach to activate the immune system using de-novo designed cyclic peptides. DNA nanotechnology is a vital part of this strategy, as it allows for fine-tuning of highly specific, multimeric interactions that are needed for immune activation.
Starting in 2013 Sebastiaan studied Biomedical Engineering at Eindhoven University of Technology. During the course of his Bachelor and Master education his interests have driven him towards a specialization in biochemistry, drug-development and synthetic biology. He performed his master thesis in the Chemical Biology group of prof.dr.ir. Luc Brunsveld. Here his research was focused on exploiting the scaffold function of protein 14-3-3, to create protein clusters within bulk solutions, similar to the functioning of membranelles organelles. Additionally, he did an internship at the Max Planck Institute of Colloids and Interfaces in the group of dr. Tom Robinson.